Although frontline combination chemotherapy can result in durable responses, approximately one‐third of patients with HL will not have a complete response (CR) to frontline treatment, are refractory to frontline treatment, or will relapse. Of the patients who either don't experience a CR to frontline therapy or relapse, only 50% will be effectively salvaged with thestandard of care for patients with relapsed or refractory HL, which is salvage chemotherapy followed by ASCT. Thus, approximately half of all of these HL patients experience disease relapse. The NCCN Guidelines recommend second‐line systemic therapy followed by response assessment with PET for all patients. Furthermore, the guidelines include everolimus and BV as options for second‐line systemic therapy for patients with relapsed or refractory CHL and bendamustine and lenalidomide for third‐line therapy.
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In accordance with the ACCME Standards for Commercial Support, Haymarket Medical Education requires that individuals in a position to control the content of an educational activity disclose all relevant financial relationships with any commercial interest. HME resolves all conflicts of interest to ensure independence, objectivity, balance, and scientific rigor in all its educational programs. Disclosures are as follows: Craig Moskowitz, MD:
Celgene Corporation, Genentech BioOncology, Merck, Seattle Genetics (consulting fee);Pharmacyclics, Seattle Genetics (contracted research).
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